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Closing the Gates of Brain Deterioration

May 25, 2019 @ 1:00 pm - 2:00 pm

new webinar FMU guest lecture series

Closing the Gates of Brain Deterioration

Speaker: Thomas O’Bryan, DC, CCN, DACBN


Degradation (a Breach) of the Blood Brain Barrier (B4), has been identified as the Gateway in development of brain inflammation.

Practically every clinical presentation of brain dysfunction has inflammation as the initiating and/or propagating mechanism.

Tight Junctions (TJ) are complex and dynamic structures involved in several key functions
of epithelial and endothelial barriers under physiological conditions as well as in pathological circumstances. TJs regulate paracellular trafficking and fluid flow from plasma to extravascular spaces between endothelial cells and epithelial cells.  This function is seen in epithelial linings of the gut, lungs and brain.

Intestinal epithelial TJ Proteins have been identified as biomarkers in the development of autoimmune diseases. These same proteins have been identified in epithelial lining of the Blood Brain Barrier.

The expression of zonulin is one of a number of biomarkers correlated to the degradation of the blood-brain barrier. Thus biomarkers of pathogenic intestinal permeability may be indicators of B4.

Food Sensitivities have been identified as contributing to B4, while other food selections
have been shown to reduce B4. How does one know?

This presentation will address:

  1. Laboratory testing identifying a Breach of the Blood Brain
    Barrier (B4)
  2. It’s contributing factors
  3. And protocols to address the ‘Leaky Brain’.


May 25, 2019
1:00 pm - 2:00 pm


Functional Medicine University


Dr. Ron Grisanti

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